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- References [9]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11685-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11685-1-AP, RRID:AB_2252364
- Product name
- PLEK2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PLEK2 antibody (Cat. #11685-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Pleckstrin-2 as a Prognostic Factor and Mediator of Gastric Cancer Progression.
TGF-β-induced PLEK2 promotes metastasis and chemoresistance in oesophageal squamous cell carcinoma by regulating LCN2.
Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation.
PLEK2 promotes osteosarcoma tumorigenesis and metastasis by activating the PI3K/AKT signaling pathway.
microRNA-873 inhibits self-renewal and proliferation of pancreatic cancer stem cells through pleckstrin-2-dependent PI3K/AKT pathway.
PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway.
Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.
Human trophoblast epithelial-mesenchymal transition in abnormally invasive placenta.
Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis.
Wang J, He Z, Sun B, Huang W, Xiang J, Chen Z, Li Z, Gu X
Gastroenterology research and practice 2021;2021:5527387
Gastroenterology research and practice 2021;2021:5527387
TGF-β-induced PLEK2 promotes metastasis and chemoresistance in oesophageal squamous cell carcinoma by regulating LCN2.
Wang F, Zhang C, Cheng H, Liu C, Lu Z, Zheng S, Wang S, Sun N, He J
Cell death & disease 2021 Oct 2;12(10):901
Cell death & disease 2021 Oct 2;12(10):901
Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation.
Feola M, Zamperone A, Moskop D, Chen H, Casu C, Lama D, Di Martino J, Djedaini M, Papa L, Martinez MR, Choesang T, Bravo-Cordero JJ, MacKay M, Zumbo P, Brinkman N, Abrams CS, Rivella S, Hattangadi S, Mason CE, Hoffman R, Ji P, Follenzi A, Ginzburg YZ
Communications biology 2021 May 3;4(1):517
Communications biology 2021 May 3;4(1):517
PLEK2 promotes osteosarcoma tumorigenesis and metastasis by activating the PI3K/AKT signaling pathway.
Liu Y, Yang S, Wang F, Zhou Z, Xu W, Xie J, Qiao L, Gu Y
Oncology letters 2021 Jul;22(1):534
Oncology letters 2021 Jul;22(1):534
microRNA-873 inhibits self-renewal and proliferation of pancreatic cancer stem cells through pleckstrin-2-dependent PI3K/AKT pathway.
Yang XL, Ma YS, Liu YS, Jiang XH, Ding H, Shi Y, Jia CY, Lu GX, Zhang DD, Wang HM, Wang PY, Lv ZW, Yu F, Liu JB, Fu D
Cellular signalling 2021 Aug;84:110025
Cellular signalling 2021 Aug;84:110025
PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway.
Shen H, He M, Lin R, Zhan M, Xu S, Huang X, Xu C, Chen W, Yao Y, Mohan M, Wang J
Journal of experimental & clinical cancer research : CR 2019 Jun 10;38(1):247
Journal of experimental & clinical cancer research : CR 2019 Jun 10;38(1):247
Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.
Zhao B, Mei Y, Cao L, Zhang J, Sumagin R, Yang J, Gao J, Schipma MJ, Wang Y, Thorsheim C, Zhao L, Stalker T, Stein B, Wen QJ, Crispino JD, Abrams CS, Ji P
The Journal of clinical investigation 2018 Jan 2;128(1):125-140
The Journal of clinical investigation 2018 Jan 2;128(1):125-140
Human trophoblast epithelial-mesenchymal transition in abnormally invasive placenta.
DaSilva-Arnold SC, Zamudio S, Al-Khan A, Alvarez-Perez J, Mannion C, Koenig C, Luke D, Perez AM, Petroff M, Alvarez M, Illsley NP
Biology of reproduction 2018 Aug 1;99(2):409-421
Biology of reproduction 2018 Aug 1;99(2):409-421
Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis.
Zhao B, Keerthivasan G, Mei Y, Yang J, McElherne J, Wong P, Doench JG, Feng G, Root DE, Ji P
Haematologica 2014 Jul;99(7):1157-67
Haematologica 2014 Jul;99(7):1157-67
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 11685-1-AP(PLEK2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PLEK2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PLEK2. This antibody recognizes human, mouse, rat antigen. The PLEK2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
