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Learn15497-1-AP
antibody from Proteintech Group
Targeting: TNFRSF10B
CD262, DR5, KILLER, TRAIL-R2, TRAILR2, TRICK2A, TRICKB
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ELISAAntibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 15497-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15497-1-AP, RRID:AB_2240702
- Product name
- DR5-Specific antibody
- Antibody type
- Polyclonal
- Description
- DR5-Specific antibody (Cat. #15497-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TRAIL produced by SAM-1-activated CD4+ and CD8+ subgroup T cells induces apoptosis in human tumor cells through upregulation of death receptors.
YM155 sensitizes HeLa cells to TRAIL-mediated apoptosis via cFLIP and survivin downregulation.
Luteolin enhances TRAIL sensitivity in non-small cell lung cancer cells through increasing DR5 expression and Drp1-mediated mitochondrial fission.
CRISPR-mediated upregulation of DR5 and downregulation of cFLIP synergistically sensitize HeLa cells to TRAIL-mediated apoptosis.
Trail armed oncolytic poxvirus suppresses lung cancer cell by inducing apoptosis.
Discovery and Characterization of 4-Hydroxy-2-pyridone Derivative Sambutoxin as a Potent and Promising Anticancer Drug Candidate: Activity and Molecular Mechanism.
A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure.
Pro-survival effects by NF-κB, Akt and ERK(1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer.
Zhang G, Xu M, Zhang X, Ma L, Zhang H
Toxicology and applied pharmacology 2021 Sep 15;427:115656
Toxicology and applied pharmacology 2021 Sep 15;427:115656
YM155 sensitizes HeLa cells to TRAIL-mediated apoptosis via cFLIP and survivin downregulation.
Chandrasekaran AP, Poondla N, Ko NR, Oh SJ, Ramakrishna S
Oncology letters 2020 Oct;20(4):72
Oncology letters 2020 Oct;20(4):72
Luteolin enhances TRAIL sensitivity in non-small cell lung cancer cells through increasing DR5 expression and Drp1-mediated mitochondrial fission.
Wu B, Xiong J, Zhou Y, Wu Y, Song Y, Wang N, Chen L, Zhang J
Archives of biochemistry and biophysics 2020 Oct 15;692:108539
Archives of biochemistry and biophysics 2020 Oct 15;692:108539
CRISPR-mediated upregulation of DR5 and downregulation of cFLIP synergistically sensitize HeLa cells to TRAIL-mediated apoptosis.
Poondla N, Chandrasekaran AP, Heese K, Kim KS, Ramakrishna S
Biochemical and biophysical research communications 2019 Apr 23;512(1):60-65
Biochemical and biophysical research communications 2019 Apr 23;512(1):60-65
Trail armed oncolytic poxvirus suppresses lung cancer cell by inducing apoptosis.
Hu J, Wang H, Gu J, Liu X, Zhou X
Acta biochimica et biophysica Sinica 2018 Oct 1;50(10):1018-1027
Acta biochimica et biophysica Sinica 2018 Oct 1;50(10):1018-1027
Discovery and Characterization of 4-Hydroxy-2-pyridone Derivative Sambutoxin as a Potent and Promising Anticancer Drug Candidate: Activity and Molecular Mechanism.
Li LN, Wang L, Cheng YN, Cao ZQ, Zhang XK, Guo XL
Molecular pharmaceutics 2018 Nov 5;15(11):4898-4911
Molecular pharmaceutics 2018 Nov 5;15(11):4898-4911
A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure.
Yao Y, Lu Q, Hu Z, Yu Y, Chen Q, Wang QK
Nature communications 2017 Jul 25;8(1):133
Nature communications 2017 Jul 25;8(1):133
Pro-survival effects by NF-κB, Akt and ERK(1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer.
Yang J, Li G, Zhang K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Dec;84:1078-1087
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Dec;84:1078-1087
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DR5-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human DR5-Specific. This antibody recognizes human antigen. The DR5-Specific antibody has been validated for the following applications: ELISA, WB analysis.
