RREB1

The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Description

Ras responsive element binding protein 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli fibrillar center, Nuclear speckles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

6 (7107597 - 7251980)

Ensembl ID

ENSG00000124782  (ver. 103.38)

Orthologs

Mouse Rreb1: ENSMUSG00000039087

UniProt

Q92766

neXtProt

NX_Q92766

Human splice variants
Mouse splice variants

Protein structure