- HPA002110 - Atlas Antibodies PODXL antibody

Submitted references Prognostic and predictive significance of podocalyxin-like protein expression in pancreatic and periampullary adenocarcinoma.

Heby M, Elebro J, Nodin B, Jirström K, Eberhard J
BMC clinical pathology 2015;15:10

Podocalyxin Is a Marker of Poor Prognosis in Pancreatic Ductal Adenocarcinoma

Saukkonen K, Hagström J, Mustonen H, Juuti A, Nordling S, Fermér C, Nilsson O, Seppänen H, Haglund C, Real F
PLOS ONE 2015 June;10(6)

Proteome-wide Epitope Mapping of Antibodies Using Ultra-dense Peptide Arrays

Forsstrom B, Axnas B, Stengele K, Buhler J, Albert T, Richmond T, Hu F, Nilsson P, Hudson E, Rockberg J, Uhlen M
Molecular & Cellular Proteomics 2014 June;13(6):1585-1597

Membranous expression of podocalyxin-like protein is an independent factor of poor prognosis in urothelial bladder cancer.

Boman K, Larsson AH, Segersten U, Kuteeva E, Johannesson H, Nodin B, Eberhard J, Uhlén M, Malmström PU, Jirström K
British journal of cancer 2013 Jun 11;108(11):2321-8

Sialofucosylated podocalyxin is a functional E- and L-selectin ligand expressed by metastatic pancreatic cancer cells.

Dallas MR, Chen SH, Streppel MM, Sharma S, Maitra A, Konstantopoulos K
American journal of physiology. Cell physiology 2012 Sep 15;303(6):C616-24

Methylation of an intronic region regulates miR-199a in testicular tumor malignancy

Cheung H, Davis A, Lee T, Pang A, Nagrani S, Rennert O, Chan W
Oncogene 2011 March;30(31):3404-3415

Overexpression of podocalyxin-like protein is an independent factor of poor prognosis in colorectal cancer

Larsson A, Johansson M, Wangefjord S, Gaber A, Nodin B, Kucharzewska P, Welinder C, Belting M, Eberhard J, Johnsson A, Uhlén M, Jirström K
British Journal of Cancer 2011 August;105(5):666-672

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoli, plasma membrane, microtubule organizing center & vesicles.
Sample type: HUMAN

Enhanced validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Orthogonal validation
Main image
Experimental details: Immunohistochemistry analysis in human kidney and liver tissues using HPA002110 antibody. Corresponding PODXL RNA-seq data are presented for the same tissues.
Sample type: HUMAN
Orthogonal method: Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in glomeruli.

Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunohistochemical staining of human kidney shows high expression.
Sample type: HUMAN

Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunohistochemical staining of human liver shows low expression as expected.
Sample type: HUMAN

Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunohistochemical staining of human rectum shows strong membranous positivity in endothelial cells.
Sample type: HUMAN

Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunohistochemical staining of human fallopian tube shows strong positivity in cilia in glandular cells.
Sample type: HUMAN

Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunohistochemical staining of human liver shows no positivity in hepatocytes as expected.
Sample type: HUMAN

Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunohistochemical staining of human kidney shows strong membranous positivity in cells in glomeruli.
Sample type: HUMAN

HPA002110

Antibody data