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- References [10]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11345-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11345-1-AP, RRID:AB_2216189
- Product name
- NSD3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NSD3 antibody (Cat. #11345-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: FC, IF, IHC, WB, ELISA.
- Reactivity
- Human, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references High WHSC1L1 Expression Reduces Survival Rates in Operated Breast Cancer Patients with Decreased CD8+ T Cells: Machine Learning Approach.
NSD3-Induced Methylation of H3K36 Activates NOTCH Signaling to Drive Breast Tumor Initiation and Metastatic Progression.
Development of mammary hyperplasia, dysplasia, and invasive ductal carcinoma in transgenic mice expressing the 8p11 amplicon oncogene NSD3.
WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR in head and neck cancer.
NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation.
Amplification of WHSC1L1 regulates expression and estrogen-independent activation of ERα in SUM-44 breast cancer cells and is associated with ERα over-expression in breast cancer.
WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck.
Identification of druggable cancer driver genes amplified across TCGA datasets.
The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis.
Transforming properties of 8p11-12 amplified genes in human breast cancer.
Kim HS, Min KW, Kim DH, Son BK, Kwon MJ, Hong SM
Journal of personalized medicine 2021 Jul 5;11(7)
Journal of personalized medicine 2021 Jul 5;11(7)
NSD3-Induced Methylation of H3K36 Activates NOTCH Signaling to Drive Breast Tumor Initiation and Metastatic Progression.
Jeong GY, Park MK, Choi HJ, An HW, Park YU, Choi HJ, Park J, Kim HY, Son T, Lee H, Min KW, Oh YH, Lee JY, Kong G
Cancer research 2021 Jan 1;81(1):77-90
Cancer research 2021 Jan 1;81(1):77-90
Development of mammary hyperplasia, dysplasia, and invasive ductal carcinoma in transgenic mice expressing the 8p11 amplicon oncogene NSD3.
Turner-Ivey B, Smith EL, Rutkovsky AC, Spruill LS, Mills JN, Ethier SP
Breast cancer research and treatment 2017 Jul;164(2):349-358
Breast cancer research and treatment 2017 Jul;164(2):349-358
WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR in head and neck cancer.
Saloura V, Vougiouklakis T, Zewde M, Deng X, Kiyotani K, Park JH, Matsuo Y, Lingen M, Suzuki T, Dohmae N, Hamamoto R, Nakamura Y
Scientific reports 2017 Jan 19;7:40664
Scientific reports 2017 Jan 19;7:40664
NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation.
García-Carpizo V, Sarmentero J, Han B, Graña O, Ruiz-Llorente S, Pisano DG, Serrano M, Brooks HB, Campbell RM, Barrero MJ
Scientific reports 2016 Sep 8;6:32952
Scientific reports 2016 Sep 8;6:32952
Amplification of WHSC1L1 regulates expression and estrogen-independent activation of ERα in SUM-44 breast cancer cells and is associated with ERα over-expression in breast cancer.
Irish JC, Mills JN, Turner-Ivey B, Wilson RC, Guest ST, Rutkovsky A, Dombkowski A, Kappler CS, Hardiman G, Ethier SP
Molecular oncology 2016 Jun;10(6):850-65
Molecular oncology 2016 Jun;10(6):850-65
WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck.
Saloura V, Vougiouklakis T, Zewde M, Kiyotani K, Park JH, Gao G, Karrison T, Lingen M, Nakamura Y, Hamamoto R
Oncotarget 2016 Jul 5;7(27):42527-42538
Oncotarget 2016 Jul 5;7(27):42527-42538
Identification of druggable cancer driver genes amplified across TCGA datasets.
Chen Y, McGee J, Chen X, Doman TN, Gong X, Zhang Y, Hamm N, Ma X, Higgs RE, Bhagwat SV, Buchanan S, Peng SB, Staschke KA, Yadav V, Yue Y, Kouros-Mehr H
PloS one 2014;9(5):e98293
PloS one 2014;9(5):e98293
The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis.
Kang D, Cho HS, Toyokawa G, Kogure M, Yamane Y, Iwai Y, Hayami S, Tsunoda T, Field HI, Matsuda K, Neal DE, Ponder BA, Maehara Y, Nakamura Y, Hamamoto R
Genes, chromosomes & cancer 2013 Feb;52(2):126-39
Genes, chromosomes & cancer 2013 Feb;52(2):126-39
Transforming properties of 8p11-12 amplified genes in human breast cancer.
Yang ZQ, Liu G, Bollig-Fischer A, Giroux CN, Ethier SP
Cancer research 2010 Nov 1;70(21):8487-97
Cancer research 2010 Nov 1;70(21):8487-97
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 11345-1-AP(WHSC1L1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NSD3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NSD3. This antibody recognizes human,mouse,rat antigen. The NSD3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
