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- Antibody Data
- Antigen structure
- References [26]
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- Western blot [1]
- Other assay [2]
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- Product number
- MA5-13390 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Thrombospondin 1 Monoclonal Antibody (C6.7)
- Antibody type
- Monoclonal
- Antigen
- Purifed from natural sources
- Description
- MA5-13390 targets Thrombospondin in FACS, IF, IM, IP, and WB applications and shows reactivity with Bovine, Canine, Equine, Human, Ovine, Porcine, and Rat samples. The MA5-13390 immunogen is ca2+-replete, native purified human TSP from supernatant of thrombin-activated platelets.
- Reactivity
- Human, Rat, Bovine, Canine, Porcine
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- C6.7
- Vial size
- 500 µL
- Concentration
- 0.2 mg/mL
- Storage
- 4° C
Submitted references Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme.
The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte Elimination.
Adipose-derived stromal vascular fraction cells isolated from old animals exhibit reduced capacity to support the formation of microvascular networks.
Adenosine stimulates angiogenesis by up-regulating production of thrombospondin-1 by macrophages.
Regulation of T-lymphocyte motility, adhesion and de-adhesion by a cell surface mechanism directed by low density lipoprotein receptor-related protein 1 and endogenous thrombospondin-1.
Bystander senescence in human peritoneal mesothelium and fibroblasts is related to thrombospondin-1-dependent activation of transforming growth factor-β1.
A cytokine-controlled mechanism for integrated regulation of T-lymphocyte motility, adhesion and activation.
Morphine modulation of thrombospondin levels in astrocytes and its implications for neurite outgrowth and synapse formation.
Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease.
Phosphatidylserine-positive erythrocytes bind to immobilized and soluble thrombospondin-1 via its heparin-binding domain.
Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations.
Novel CD47-dependent intercellular adhesion modulates cell migration.
Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction.
Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction.
Thrombospondin-1 and indoleamine 2,3-dioxygenase are major targets of extracellular ATP in human dendritic cells.
Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism.
Thrombospondin 1 is an autocrine negative regulator of human dendritic cell activation.
CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum.
Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling.
Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling.
Adhesion of normal erythrocytes at depressed venous shear rates to activated neutrophils, activated platelets, and fibrin polymerized from plasma.
T lymphocyte expression of thrombospondin-1 and adhesion to extracellular matrix components.
Mechanism of interaction of thrombospondin with human endothelium and inhibition of sickle erythrocyte adhesion to human endothelial cells by heparin.
Mechanism of interaction of thrombospondin with human endothelium and inhibition of sickle erythrocyte adhesion to human endothelial cells by heparin.
Calcium-induced modification of protein conformation demonstrated by immunohistochemistry: What is the signal?
Calcium-induced modification of protein conformation demonstrated by immunohistochemistry: What is the signal?
Jacquemin G, Wurmser A, Huyghe M, Sun W, Homayed Z, Merle C, Perkins M, Qasrawi F, Richon S, Dingli F, Arras G, Loew D, Vignjevic D, Pannequin J, Fre S
eLife 2022 May 11;11
eLife 2022 May 11;11
The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte Elimination.
Beguier F, Housset M, Roubeix C, Augustin S, Zagar Y, Nous C, Mathis T, Eandi C, Benchaboune M, Drame-Maigné A, Carpentier W, Chardonnet S, Touhami S, Blot G, Conart JB, Charles-Messance H, Potey A, Girmens JF, Paques M, Blond F, Leveillard T, Koertvely E, Roger JE, Sahel JA, Sapieha P, Delarasse C, Guillonneau X, Sennlaub F
Immunity 2020 Aug 18;53(2):429-441.e8
Immunity 2020 Aug 18;53(2):429-441.e8
Adipose-derived stromal vascular fraction cells isolated from old animals exhibit reduced capacity to support the formation of microvascular networks.
Aird AL, Nevitt CD, Christian K, Williams SK, Hoying JB, LeBlanc AJ
Experimental gerontology 2015 Mar;63:18-26
Experimental gerontology 2015 Mar;63:18-26
Adenosine stimulates angiogenesis by up-regulating production of thrombospondin-1 by macrophages.
Ernens I, Bousquenaud M, Lenoir B, Devaux Y, Wagner DR
Journal of leukocyte biology 2015 Jan;97(1):9-18
Journal of leukocyte biology 2015 Jan;97(1):9-18
Regulation of T-lymphocyte motility, adhesion and de-adhesion by a cell surface mechanism directed by low density lipoprotein receptor-related protein 1 and endogenous thrombospondin-1.
Talme T, Bergdahl E, Sundqvist KG
Immunology 2014 Jun;142(2):176-92
Immunology 2014 Jun;142(2):176-92
Bystander senescence in human peritoneal mesothelium and fibroblasts is related to thrombospondin-1-dependent activation of transforming growth factor-β1.
Mikuła-Pietrasik J, Sosińska P, Janus J, Rubiś B, Brewińska-Olchowik M, Piwocka K, Książek K
The international journal of biochemistry & cell biology 2013 Sep;45(9):2087-96
The international journal of biochemistry & cell biology 2013 Sep;45(9):2087-96
A cytokine-controlled mechanism for integrated regulation of T-lymphocyte motility, adhesion and activation.
Bergström SE, Bergdahl E, Sundqvist KG
Immunology 2013 Dec;140(4):441-55
Immunology 2013 Dec;140(4):441-55
Morphine modulation of thrombospondin levels in astrocytes and its implications for neurite outgrowth and synapse formation.
Ikeda H, Miyatake M, Koshikawa N, Ochiai K, Yamada K, Kiss A, Donlin MJ, Panneton WM, Churchill JD, Green M, Siddiqui AM, Leinweber AL, Crews NR, Ezerskiy LA, Rendell VR, Belcheva MM, Coscia CJ
The Journal of biological chemistry 2010 Dec 3;285(49):38415-27
The Journal of biological chemistry 2010 Dec 3;285(49):38415-27
Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease.
Kukreja A, Radfar S, Sun BH, Insogna K, Dhodapkar MV
Blood 2009 Oct 15;114(16):3413-21
Blood 2009 Oct 15;114(16):3413-21
Phosphatidylserine-positive erythrocytes bind to immobilized and soluble thrombospondin-1 via its heparin-binding domain.
Gayen Betal S, Setty BN
Translational research : the journal of laboratory and clinical medicine 2008 Oct;152(4):165-77
Translational research : the journal of laboratory and clinical medicine 2008 Oct;152(4):165-77
Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations.
Annis DS, Gunderson KA, Mosher DF
The Journal of biological chemistry 2007 Sep 14;282(37):27067-27075
The Journal of biological chemistry 2007 Sep 14;282(37):27067-27075
Novel CD47-dependent intercellular adhesion modulates cell migration.
Rebres RA, Kajihara K, Brown EJ
Journal of cellular physiology 2005 Nov;205(2):182-93
Journal of cellular physiology 2005 Nov;205(2):182-93
Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction.
Li SS, Forslöw A, Sundqvist KG
Journal of immunology (Baltimore, Md. : 1950) 2005 Jan 15;174(2):654-61
Journal of immunology (Baltimore, Md. : 1950) 2005 Jan 15;174(2):654-61
Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction.
Li SS, Forslöw A, Sundqvist KG
Journal of immunology (Baltimore, Md. : 1950) 2005 Jan 15;174(2):654-61
Journal of immunology (Baltimore, Md. : 1950) 2005 Jan 15;174(2):654-61
Thrombospondin-1 and indoleamine 2,3-dioxygenase are major targets of extracellular ATP in human dendritic cells.
Marteau F, Gonzalez NS, Communi D, Goldman M, Boeynaems JM, Communi D
Blood 2005 Dec 1;106(12):3860-6
Blood 2005 Dec 1;106(12):3860-6
Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism.
Emonard H, Bellon G, Troeberg L, Berton A, Robinet A, Henriet P, Marbaix E, Kirkegaard K, Patthy L, Eeckhout Y, Nagase H, Hornebeck W, Courtoy PJ
The Journal of biological chemistry 2004 Dec 24;279(52):54944-51
The Journal of biological chemistry 2004 Dec 24;279(52):54944-51
Thrombospondin 1 is an autocrine negative regulator of human dendritic cell activation.
Doyen V, Rubio M, Braun D, Nakajima T, Abe J, Saito H, Delespesse G, Sarfati M
The Journal of experimental medicine 2003 Oct 20;198(8):1277-83
The Journal of experimental medicine 2003 Oct 20;198(8):1277-83
CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum.
Smith TG, Serghides L, Patel SN, Febbraio M, Silverstein RL, Kain KC
Infection and immunity 2003 Jan;71(1):393-400
Infection and immunity 2003 Jan;71(1):393-400
Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling.
Lopes N, Gregg D, Vasudevan S, Hassanain H, Goldschmidt-Clermont P, Kovacic H
Molecular and cellular biology 2003 Aug;23(15):5401-8
Molecular and cellular biology 2003 Aug;23(15):5401-8
Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling.
Lopes N, Gregg D, Vasudevan S, Hassanain H, Goldschmidt-Clermont P, Kovacic H
Molecular and cellular biology 2003 Aug;23(15):5401-8
Molecular and cellular biology 2003 Aug;23(15):5401-8
Adhesion of normal erythrocytes at depressed venous shear rates to activated neutrophils, activated platelets, and fibrin polymerized from plasma.
Goel MS, Diamond SL
Blood 2002 Nov 15;100(10):3797-803
Blood 2002 Nov 15;100(10):3797-803
T lymphocyte expression of thrombospondin-1 and adhesion to extracellular matrix components.
Li SS, Ivanoff A, Bergström SE, Sandström A, Christensson B, van Nerven J, Holgersson J, Hauzenberger D, Arencibia I, Sundqvist KG
European journal of immunology 2002 Apr;32(4):1069-79
European journal of immunology 2002 Apr;32(4):1069-79
Mechanism of interaction of thrombospondin with human endothelium and inhibition of sickle erythrocyte adhesion to human endothelial cells by heparin.
Gupta K, Gupta P, Solovey A, Hebbel RP
Biochimica et biophysica acta 1999 Jan 6;1453(1):63-73
Biochimica et biophysica acta 1999 Jan 6;1453(1):63-73
Mechanism of interaction of thrombospondin with human endothelium and inhibition of sickle erythrocyte adhesion to human endothelial cells by heparin.
Gupta K, Gupta P, Solovey A, Hebbel RP
Biochimica et biophysica acta 1999 Jan 6;1453(1):63-73
Biochimica et biophysica acta 1999 Jan 6;1453(1):63-73
Calcium-induced modification of protein conformation demonstrated by immunohistochemistry: What is the signal?
Shi SR, Cote RJ, Hawes D, Thu S, Shi Y, Young LL, Taylor CR
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 Apr;47(4):463-70
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 Apr;47(4):463-70
Calcium-induced modification of protein conformation demonstrated by immunohistochemistry: What is the signal?
Shi SR, Cote RJ, Hawes D, Thu S, Shi Y, Young LL, Taylor CR
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 Apr;47(4):463-70
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 Apr;47(4):463-70
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot of Thrombospondin using Thrombospondin Monoclonal Antibody (Product # MA5-13390) on HUVEC Cells.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunoprecipitation of Thrombospondin using Thrombospondin Monoclonal Antibody (Product # MA5-13390) on Native Human HUVEC Cells.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
