CLCA1

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]

Description

Chloride channel accessory 1

Tissue specificity

Tissue enriched (intestine)

Predicted location

Secreted to digestive system

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Transporters

Chromosome

1 (86468368 - 86500259)

Ensembl ID

ENSG00000016490  (ver. 103.38)

Orthologs

Mouse Clca1: ENSMUSG00000028255

UniProt

A8K7I4

neXtProt

NX_A8K7I4

Human splice variants
Mouse splice variants

Protein structure