ITIH1

This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. [provided by RefSeq, Nov 2015]

Description

Inter-alpha-trypsin inhibitor heavy chain 1

Tissue specificity

Tissue enriched (liver)

Subcell location

Vesicles

Predicted location

Intracellular, Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (52777595 - 52792068)

Ensembl ID

ENSG00000055957  (ver. 103.38)

Orthologs

Mouse Itih1: ENSMUSG00000006529

UniProt

P19827

neXtProt

NX_P19827

Human splice variants
Mouse splice variants

Protein structure