TSPAN32

This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Description

Tetraspanin 32

Tissue specificity

Group enriched (bone marrow, heart muscle, lymphoid tissue)

Subcell location

Nucleoplasm

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

11 (2301997 - 2318204)

Ensembl ID

ENSG00000064201  (ver. 103.38)

Orthologs

Mouse Tspan32: ENSMUSG00000000244

UniProt

Q96QS1

neXtProt

NX_Q96QS1

Human splice variants
Mouse splice variants

Protein structure