Tissue expression
Cell line expression
Protein structure
SEMA3C
Semaphorin 3CSEMAE, SemE
This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]
Top validated antibodies |
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R&D Systems | AF1728 | 1 references | Polyclonal |
WB
ICC
IHC
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Novus Biologicals | AF1728 | 1 references | Polyclonal |
WB
ICC
IHC
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Invitrogen Antibodies | PA5-24997 | 2 references | Polyclonal |
WB
OA |
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Biorbyt | orb2241280 | Polyclonal |
WB
EL
ICC
IHC |
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Proteintech Group | 19242-1-AP | 1 references | Polyclonal |
WB
EL |
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Supportive data in Antibodypedia
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