Tissue expression
Cell line expression
Protein structure
SESN1
Sestrin 1PA26, SEST1
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Top validated antibodies |
|||||
NSJ Bioreagents | RQ8209 | Polyclonal |
WB
EL
ICC
FC |
||
Proteintech Group | 55010-1-AP | 1 references | Polyclonal |
WB
EL
IP
|
|
GeneTex | GTX118141 | 4 references | Polyclonal |
WB
IHC |
|
antibodies-online | ABIN2505307 | Polyclonal |
WB
EL
ICC
IHC |
||
LSBio | LS-C120385 | Polyclonal |
WB
EL
IHC
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider