GGA1

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Golgi associated, gamma adaptin ear containing, ARF binding protein 1

Tissue specificity

Tissue enhanced (testis)

Subcell location

Nucleoplasm, Golgi apparatus, Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

22 (37608725 - 37633564)

Ensembl ID

ENSG00000100083  (ver. 103.38)

Orthologs

Mouse Gga1: ENSMUSG00000033128

UniProt

Q9UJY5

neXtProt

NX_Q9UJY5

Human splice variants
Mouse splice variants

Protein structure