Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
RNASEH2A
Ribonuclease H2 subunit AAGS4, RNASEHI, RNHIA, RNHL
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid. [provided by RefSeq, Aug 2009]
Top validated antibodies |
|||||
| Proteintech Group |  16132-1-AP |
8 references | Polyclonal |
WB
EL
IP
IHC
|
|
| Novus Biologicals | NBP1-76981 |
2 references | Polyclonal |
WB
EL
ICC
IP
|
|
| LSBio | LS-C30721 |
Polyclonal |
WB
IHC
|
||
| Invitrogen Antibodies | 16132-1-AP |
Polyclonal |
WB
IP
IHC
OA
|
||
| antibodies-online | ABIN500622 |
4 references | Polyclonal |
WB
EL
ICC
|
|
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive) Recommended by provider