IL27RA

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]

Description

Interleukin 27 receptor subunit alpha

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Vesicles

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (14031762 - 14053218)

Ensembl ID

ENSG00000104998  (ver. 103.38)

Orthologs

Mouse Il27ra: ENSMUSG00000005465

UniProt

Q6UWB1

neXtProt

NX_Q6UWB1

Human splice variants
Mouse splice variants

Protein structure