ALOX12

This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]

Description

Arachidonate 12-lipoxygenase, 12S type

Tissue specificity

Tissue enhanced (esophagus, vagina)

Subcell location

Nuclear speckles, Vesicles, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (6996049 - 7010754)

Ensembl ID

ENSG00000108839  (ver. 103.38)

Orthologs

Mouse Alox12: ENSMUSG00000000320

UniProt

P18054

neXtProt

NX_P18054

Human splice variants
Mouse splice variants

Protein structure