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Protein structure
IL10RA
Interleukin 10 receptor subunit alphaCD210, CD210a, CDW210A, HIL-10R, IL10R
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
Top validated antibodies |
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| R&D Systems |  AF-274-NA |
2 references | Polyclonal |
WB
ICC
BN
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| Invitrogen Antibodies | PA5-109852 |
1 references | Polyclonal |
WB
ICC
IHC
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| antibodies-online | ABIN2842473 |
1 references | Polyclonal |
WB
ICC
FC
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| Novus Biologicals | AF-274-NA |
2 references | Polyclonal |
WB
ICC
BN
|
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| Abnova Corporation | PAB18395 |
2 references | Polyclonal |
WB
ICC
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