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Protein structure
CDKN1B
Cyclin dependent kinase inhibitor 1BKIP1, P27KIP1
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
Top validated antibodies |
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| Proteintech Group |  25614-1-AP |
102 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Invitrogen Antibodies | 25614-1-AP |
Polyclonal |
WB
ICC
IP
IHC
FC
OA
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| GeneTex | GTX100446 |
14 references | Polyclonal |
WB
ICC
IP
IHC
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| Novus Biologicals | H00001027-M01 |
1 references | Monoclonal |
WB
EL
ICC
IHC
PLA
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| antibodies-online | ABIN4948200 |
5 references | Monoclonal |
WB
EL
ICC
IHC
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