PLA2G2D

This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

Description

Phospholipase A2 group IID

Tissue specificity

Tissue enriched (lymphoid tissue)

Predicted location

Secreted in other tissues

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted secreted proteins
RAS pathway related proteins

Chromosome

1 (20111939 - 20119566)

Ensembl ID

ENSG00000117215  (ver. 103.38)

Orthologs

Mouse Pla2g2d: ENSMUSG00000041202

UniProt

Q9UNK4

neXtProt

NX_Q9UNK4

Human splice variants
Mouse splice variants

Protein structure