Tissue expression
Cell line expression
Protein structure
NPPB
Natriuretic peptide BThis gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]
Top validated antibodies |
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Novus Biologicals | H00004879-M01 | 1 references | Monoclonal |
WB
EL
IP
|
|
Invitrogen Antibodies | PA5-96084 | 1 references | Polyclonal |
WB
ICC
IHC
|
|
Proteintech Group | 13299-1-AP | 12 references | Polyclonal |
EL
IHC |
|
antibodies-online | ABIN518426 | 1 references | Monoclonal |
WB
EL
IP
|
|
LSBio | LS-C370671 | Polyclonal |
WB
EL
IHC
|
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider