ZWINT

This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

ZW10 interacting kinetochore protein

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Subcell location

Nucleoplasm, Nuclear bodies, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (56357227 - 56361273)

Ensembl ID

ENSG00000122952  (ver. 103.38)

Orthologs

Mouse Zwint: ENSMUSG00000019923

UniProt

O95229

neXtProt

NX_O95229

Human splice variants
Mouse splice variants

Protein structure