Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
CSE1L
Chromosome segregation 1 likeCAS, CSE1, XPO2
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Top validated antibodies |
|||||
| GeneTex |  GTX103005 |
2 references | Polyclonal |
WB
ICC
IP
IHC
|
|
| Novus Biologicals | H00001434-M08 |
11 references | Monoclonal |
WB
EL
ICC
IHC
|
|
| Abnova Corporation | H00001434-M08 |
10 references | Monoclonal |
WB
EL
ICC
IHC
|
|
| Proteintech Group | 22219-1-AP |
10 references | Polyclonal |
WB
EL
IP
IHC
|
|
| LSBio | LS-C352042 |
Polyclonal |
WB
ICC
IP
IHC
|
||
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive) Recommended by provider