Tissue expression
Cell line expression
Protein structure
EGLN1
Egl-9 family hypoxia inducible factor 1C1orf12, HIFPH2, PHD2, SM-20, ZMYND6
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009]
Top validated antibodies |
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Novus Biologicals | ![]() |
14 references | Polyclonal |
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antibodies-online | ![]() |
66 references | Polyclonal |
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Proteintech Group | ![]() |
2 references | Polyclonal |
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GeneTex | ![]() |
Polyclonal |
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LSBio | ![]() |
Polyclonal |
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