UACA

This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution, in which the mammary gland returns to its pre-pregnant state. This protein has also been proposed to negatively regulate apoptosis based on experiments in human cell lines in which the protein was shown to interact with PRKC apoptosis WT1 regulator protein, also known as PAR-4, and inhibit translocation of the PAR-4 receptor. Autoantibodies to this protein have been identified in human patients with panuveitis and Graves' disease. Differential expression of this gene has been observed in various human cancers. [provided by RefSeq, May 2017]

Description

Uveal autoantigen with coiled-coil domains and ankyrin repeats

Tissue specificity

Tissue enhanced (skeletal muscle)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

15 (70654554 - 70763558)

Ensembl ID

ENSG00000137831  (ver. 103.38)

Orthologs

Mouse Uaca: ENSMUSG00000034485

UniProt

Q9BZF9

neXtProt

NX_Q9BZF9

Human splice variants
Mouse splice variants

Protein structure