SENP7

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]). [supplied by OMIM, Jun 2009]

Description

SUMO specific peptidase 7

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear bodies, Centrosome, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (101324205 - 101513241)

Ensembl ID

ENSG00000138468  (ver. 103.38)

Orthologs

Mouse Senp7: ENSMUSG00000052917

UniProt

Q9BQF6

neXtProt

NX_Q9BQF6

Human splice variants
Mouse splice variants

Protein structure