Tissue expression
Cell line expression
Protein structure
PPOX
Protoporphyrinogen oxidasePPO, VP
This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Invitrogen Antibodies | Polyclonal |
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| Novus Biologicals | 3 references | Monoclonal |
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| LSBio | Monoclonal |
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| Abnova Corporation | 3 references | Monoclonal |
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| Proteintech Group | 1 references | Polyclonal |
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