MS4A2

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]

Description

Membrane spanning 4-domains A2

Tissue specificity

Tissue enhanced (lung)

Predicted location

Intracellular, Membrane

Protein family

FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Chromosome

11 (60088261 - 60098467)

Ensembl ID

ENSG00000149534  (ver. 103.38)

Orthologs

Mouse Ms4a2: ENSMUSG00000024680

UniProt

Q01362

neXtProt

NX_Q01362

Human splice variants
Mouse splice variants

Protein structure