PPP1R15B

This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016]

Description

Protein phosphatase 1 regulatory subunit 15B

Tissue specificity

Tissue enhanced (bone marrow)

Subcell location

Golgi apparatus

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

1 (204403381 - 204411817)

Ensembl ID

ENSG00000158615  (ver. 103.38)

Orthologs

Mouse Ppp1r15b: ENSMUSG00000046062

UniProt

Q5SWA1

neXtProt

NX_Q5SWA1

Human splice variants
Mouse splice variants

Protein structure