WFDC8

This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains a Kunitz-inhibitor domain, in addition to three WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript variants have been found for this gene, and they encode the same protein. [provided by RefSeq, Jul 2008]

Description

WAP four-disulfide core domain 8

Tissue specificity

Tissue enriched (epididymis)

Predicted location

Secreted in male reproductive system

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

20 (45551153 - 45579326)

Ensembl ID

ENSG00000158901  (ver. 103.38)

Orthologs

Mouse Wfdc8: ENSMUSG00000070533

UniProt

Q8IUA0

neXtProt

NX_Q8IUA0

Human splice variants
Mouse splice variants

Protein structure