Tissue expression
Cell line expression
Protein structure
UBR1
Ubiquitin protein ligase E3 component n-recognin 1The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
| Novus Biologicals | 2 references | Monoclonal |
|
||
| Proteintech Group | 3 references | Polyclonal |
|
||
| antibodies-online | 1 references | Monoclonal |
|
||
| Abnova Corporation | 1 references | Monoclonal |
|
||
| LSBio | Polyclonal |
|
|||