BSN

Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, Jul 2008]

Description

Bassoon presynaptic cytomatrix protein

Tissue specificity

Tissue enriched (brain)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (49554477 - 49671549)

Ensembl ID

ENSG00000164061  (ver. 103.38)

Orthologs

Mouse Bsn: ENSMUSG00000032589

UniProt

Q9UPA5

neXtProt

NX_Q9UPA5

Human splice variants
Mouse splice variants

Protein structure