MMP10

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]

Description

Matrix metallopeptidase 10

Tissue specificity

Tissue enriched (endometrium)

Subcell location

Plasma membrane, Cytosol

Predicted location

Secreted to extracellular matrix

Protein family

Cancer-related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (102770502 - 102780628)

Ensembl ID

ENSG00000166670  (ver. 103.38)

Orthologs

-

UniProt

P09238

neXtProt

NX_P09238

Human splice variants

Protein structure