ADRB2

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019]

Description

Adrenoceptor beta 2

Tissue specificity

Low tissue specificity

Subcell location

Cytosol

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Transporters

Chromosome

5 (148826611 - 148828623)

Ensembl ID

ENSG00000169252  (ver. 103.38)

Orthologs

Mouse Adrb2: ENSMUSG00000045730

UniProt

P07550

neXtProt

NX_P07550

Human splice variants
Mouse splice variants

Protein structure