P2RY12

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Description

Purinergic receptor P2Y12

Tissue specificity

Tissue enhanced (brain, lymphoid tissue)

Predicted location

Membrane

Protein family

Disease related genes
FDA approved drug targets
G-protein coupled receptors
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

3 (151336843 - 151384753)

Ensembl ID

ENSG00000169313  (ver. 103.38)

Orthologs

Mouse P2ry12: ENSMUSG00000036353

UniProt

Q9H244

neXtProt

NX_Q9H244

Human splice variants
Mouse splice variants

Protein structure