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Protein structure
RNF139
Ring finger protein 139HRCA1, RCA1, TRC8
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| antibodies-online |  ABIN393698 |
5 references | Monoclonal |
WB
EL
IHC
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| Novus Biologicals | H00011236-M01 |
1 references | Monoclonal |
WB
EL
IHC
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| Abnova Corporation | H00011236-M01 |
1 references | Monoclonal |
WB
EL
IHC
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| LSBio | LS-B8293 |
Polyclonal |
WB
EL
IHC
BN
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| Everest Biotech | EB05902 |
Polyclonal |
WB
EL
IHC
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