CYSLTR1

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Description

Cysteinyl leukotriene receptor 1

Tissue specificity

Tissue enhanced (lymphoid tissue)

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

X (78271468 - 78327691)

Ensembl ID

ENSG00000173198  (ver. 103.38)

Orthologs

Mouse Cysltr1: ENSMUSG00000052821

UniProt

Q9Y271

neXtProt

NX_Q9Y271

Human splice variants
Mouse splice variants

Protein structure