DHX36

This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Description

DEAH-box helicase 36

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Mitochondria, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (154272546 - 154324487)

Ensembl ID

ENSG00000174953  (ver. 103.38)

Orthologs

Mouse Dhx36: ENSMUSG00000027770

UniProt

Q9H2U1

neXtProt

NX_Q9H2U1

Human splice variants
Mouse splice variants

Protein structure