Tissue expression
Cell line expression
Protein structure
GP5
Glycoprotein V plateletCD42d
Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]). [supplied by OMIM, Nov 2010]
Top validated antibodies |
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Novus Biologicals | NBP2-00071-100ug | Monoclonal |
IP
IHC
FC
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St John's Laboratory | STJ97282 | Polyclonal |
WB
EL
ICC
IHC |
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antibodies-online | ABIN3178933 | Polyclonal |
WB
EL
IHC
|
||
GeneTex | GTX33967 | Polyclonal |
WB
EL
IHC
|
||
LSBio | LS-C387667 | Polyclonal |
WB
EL
IHC
|
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