NPB

This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015]

Description

Neuropeptide B

Tissue specificity

Tissue enriched (brain)

Predicted location

Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

17 (81900745 - 81902905)

Ensembl ID

ENSG00000183979  (ver. 103.38)

Orthologs

Mouse Npb: ENSMUSG00000044034

UniProt

Q8NG41

neXtProt

NX_Q8NG41

Human splice variants
Mouse splice variants

Protein structure