Tissue expression
Cell line expression
Protein structure
SOCS1
Suppressor of cytokine signaling 1Cish1, JAB, SOCS-1, SSI-1, TIP3
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Novus Biologicals | NB100-781 | 1 references | Polyclonal |
WB
EL
ICC
IHC
FC
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Invitrogen Antibodies | PA5-27239 | 2 references | Polyclonal |
WB
ICC
IHC
OA |
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antibodies-online | ABIN263007 | 1 references | Polyclonal |
WB
EL
ICC
IHC
FC
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Everest Biotech | EB05040 | Polyclonal |
WB
EL
ICC
IHC
FC
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GeneTex | GTX100657 | 2 references | Polyclonal |
WB
ICC
IHC
|
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