CXCR3

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

Description

C-X-C motif chemokine receptor 3

Tissue specificity

Tissue enhanced (bone marrow, intestine, lymphoid tissue)

Predicted location

Membrane

Protein family

CD markers
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

X (71615916 - 71618511)

Ensembl ID

ENSG00000186810  (ver. 103.38)

Orthologs

Mouse Cxcr3: ENSMUSG00000050232

UniProt

P49682

neXtProt

NX_P49682

Human splice variants
Mouse splice variants

Protein structure