TRPV1

Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

Description

Transient receptor potential cation channel subfamily V member 1

Tissue specificity

Tissue enhanced (liver)

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Chromosome

17 (3565444 - 3609411)

Ensembl ID

ENSG00000196689  (ver. 103.38)

Orthologs

Mouse Trpv1: ENSMUSG00000005952

UniProt

Q8NER1

neXtProt

NX_Q8NER1

Human splice variants
Mouse splice variants

Protein structure