HLA-G

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Description

Major histocompatibility complex, class I, G

Tissue specificity

Group enriched (pituitary gland, placenta)

Predicted location

Membrane, Secreted to blood

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

6 (29826967 - 29831125)

Ensembl ID

ENSG00000204632  (ver. 103.38)

Orthologs

-

UniProt

P17693

neXtProt

NX_P17693

Human splice variants

Protein structure