KCNQ3

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Two variants encoding distinct isoforms have been found. [provided by RefSeq, Mar 2011]

Description

potassium voltage-gated channel, KQT-like subfamily, member 3

Protein family

Mapped to UniProt SWISS-PROT, Potential transmembrane proteins, Potentially secreted proteins, Transporters, Voltage-gated ion channels

Chromosome

8:q24.22 (133139193 - 133493200)

Ensembl ID

ENSG00000184156  (ver. 71.37)

Orthologs

Mouse Kcnq3: ENSMUSG00000056258

Human splice variants
Mouse splice variants