IDH2

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. [provided by RefSeq, Jul 2008]

Description

isocitrate dehydrogenase 2 (NADP+), mitochondrial

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Potentially secreted proteins

Chromosome

15:q26.1 (90626277 - 90645736)

Ensembl ID

ENSG00000182054  (ver. 71.37)

Orthologs

Mouse Idh2: ENSMUSG00000030541

Human splice variants
Mouse splice variants