COX15

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region. [provided by RefSeq, Jul 2008]

Description

COX15 homolog, cytochrome c oxidase assembly protein (yeast)

Protein family

Membrane proteins predicted by MDM

Chromosome

10:q24.2 (101471601 - 101491866)

Ensembl ID

ENSG00000014919  (ver. 69.37)

Orthologs

Mouse Cox15: ENSMUSG00000040018

Human splice variants
Mouse splice variants