ADAM8

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]

Description

ADAM metallopeptidase domain 8

Protein family

Membrane proteins predicted by MDM, Secreted proteins predicted by MDSP

Chromosome

10:q26.3 (135075907 - 135090372)

Ensembl ID

ENSG00000151651  (ver. 69.37)

Orthologs

Mouse Adam8: ENSMUSG00000025473

Human splice variants
Mouse splice variants