MAP3K7

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Description

mitogen-activated protein kinase kinase kinase 7

Protein family

Enzymes, Kinases, Mapped to UniProt SWISS-PROT

Chromosome

6:q15 (91223292 - 91296764)

Ensembl ID

ENSG00000135341  (ver. 71.37)

Orthologs

Mouse Map3k7: ENSMUSG00000028284

Human splice variants
Mouse splice variants