CACNA1C

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]

Description

calcium channel, voltage-dependent, L type, alpha 1C subunit

Protein family

Membrane proteins predicted by MDM, Transporters, Voltage-gated ion channels

Chromosome

12:p13.33 (2079952 - 2802108)

Ensembl ID

ENSG00000151067  (ver. 69.37)

Orthologs

Mouse Cacna1c: ENSMUSG00000051331

Human splice variants
Mouse splice variants