RASA1

The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, Jul 2008]

Description

RAS p21 protein activator (GTPase activating protein) 1

Protein family

SH2-domain containing proteins, SH3-domain containing proteins

Chromosome

5:q14.3 (86563705 - 86687748)

Ensembl ID

ENSG00000145715  (ver. 69.37)

Orthologs

Mouse Rasa1: ENSMUSG00000021549

Human splice variants
Mouse splice variants