PSMA4

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

proteasome (prosome, macropain) subunit, alpha type, 4

Protein family

Enzymes, Peptidases

Chromosome

15:q25.1 (78832747 - 78841604)

Ensembl ID

ENSG00000041357  (ver. 69.37)

Orthologs

Mouse Psma4: ENSMUSG00000032301

Human splice variants
Mouse splice variants